LTBP1 (gene)

Latent transforming growth factor beta binding protein 1

PDB rendering based on 1ksq.

Available structures
PDB	1ksq

Identifiers

Symbols

LTBP1; MGC163161

External IDs

OMIM: 150390 MGI: 109151 HomoloGene: 522 GeneCards: LTBP1 Gene

Gene Ontology
Molecular function	• transforming growth factor beta receptor activity • binding • calcium ion binding • growth factor binding
Cellular component	• extracellular region • proteinaceous extracellular matrix • extracellular matrix
Biological process	• biological_process • negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
33.17 – 33.62 Mb

Chr 17:
75.4 – 75.79 Mb

PubMed search

[1]

[2]

Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.^[1]^[2]^[3]

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

Interactions

LTBP1 (gene) has been shown to interact with TGF beta 1.^[4]

References

^ Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH (Jul 1990). "TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences". Cell 61 (6): 1051–1061. doi:10.1016/0092-8674(90)90069-Q. PMID 2350783.
^ Oklu R, Hesketh R (Jan 2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem J 352 Pt 3: 601–10. PMC 1221494. PMID 11104663. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221494.
^ ^a ^b "Entrez Gene: LTBP1 latent transforming growth factor beta binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4052.
^ Saharinen, J; Keski-Oja J (Aug. 2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell (UNITED STATES) 11 (8): 2691–704. ISSN 1059-1524. PMC 14949. PMID 10930463. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14949.

Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
Keski-Oja J, Koli K, von Melchner H (2005). "TGF-beta activation by traction?". Trends Cell Biol. 14 (12): 657–659. doi:10.1016/j.tcb.2004.10.003. PMID 15564041.
Stenman G, Sahlin P, Olofsson A et al. (1994). "Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12→q22". Cytogenet. Cell Genet. 66 (2): 117–119. doi:10.1159/000133680. PMID 8287682.
Olofsson A, Ichijo H, Morén A et al. (1996). "Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix". J. Biol. Chem. 270 (52): 31294–31297. doi:10.1074/jbc.270.52.31294. PMID 8537398.
Saharinen J, Taipale J, Keski-Oja J (1996). "Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1". EMBO J. 15 (2): 245–53. PMC 449939. PMID 8617200. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=449939.
Taipale J, Saharinen J, Hedman K, Keski-Oja J (1996). "Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils". J. Histochem. Cytochem. 44 (8): 875–89. doi:10.1177/44.8.8756760. PMID 8756760.
Nunes I, Gleizes PE, Metz CN, Rifkin DB (1997). "Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta". J. Cell Biol. 136 (5): 1151–1163. doi:10.1083/jcb.136.5.1151. PMC 2132473. PMID 9060478. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132473.
Karonen T, Jeskanen L, Keski-Oja J (1997). "Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma". Br. J. Dermatol. 137 (1): 51–58. doi:10.1111/j.1365-2133.1997.tb03700.x. PMID 9274625.
Dallas SL, Keene DR, Bruder SP et al. (2000). "Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo". J. Bone Miner. Res. 15 (1): 68–81. doi:10.1359/jbmr.2000.15.1.68. PMID 10646116.
Saharinen J, Keski-Oja J (2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell 11 (8): 2691–704. PMC 14949. PMID 10930463. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14949.
Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3". Biochem. J. 369 (Pt 2): 311–8. doi:10.1042/BJ20020809. PMC 1223078. PMID 12358597. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223078.
Isogai Z, Ono RN, Ushiro S et al. (2003). "Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein". J. Biol. Chem. 278 (4): 2750–2757. doi:10.1074/jbc.M209256200. PMID 12429738.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gui Y, Murphy LJ (2004). "Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1". Mol. Cell. Biochem. 250 (1–2): 189–195. doi:10.1023/A:1024990409102. PMID 12962157.
Weikkolainen K, Keski-Oja J, Koli K (2004). "Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts". Growth Factors 21 (2): 51–60. doi:10.1080/08977198310001598778. PMID 14626352.
Shariat SF, Kattan MW, Traxel E et al. (2004). "Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression". Clin. Cancer Res. 10 (6): 1992–1999. doi:10.1158/1078-0432.CCR-0768-03. PMID 15041717.

PDB gallery

1ksq: NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1

LTBP1 (gene)

Interactions

References

Further reading